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General Information about Molindone

April 27, 2017


Molindone (brand name: Moban) is an antipsychotic medicine used for Molindonetreatment of schizophrenia. It diminishes psychoses by blocking the effects of dopamine in brain. Although the medicine was previously discontinued by supplier Endo Pharmaceuticals from January 13, 2010, it is currently available in US from March 23, 2015under Abbreviated New Drug Application by CorePharma.

Molidone should not be used or cautiously used in case-

  • The patient is allergic to any ingredient in molindone or in fact if has any form of allergy
  • severe central nervous system depression or coma or sedation
  • The patient is on medications like sodium oxybate (GHB) or Barbiturates (eg, Phenobarbital) or narcotics (eg, codeine)
  • The  patient is pregnant or breast feeding or planning pregnancy
  • The patient has history of seizures, heart failure, heart attack, blood vessel disorders, high or low blood pressure, irregular heartbeat, slow heart beat, abnormal electrocardiogram (ECG), stroke etc.
  • If you have a history of liver diseases, stomach or bowel disorders, neuroleptic malignant syndrome (NMS) etc.
  • Parkinson disease, glaucoma, Alzheimer disease, dementia, urinary disorders, enlarged prostate etc.
  • Patients with high prolactin level or history of cancers.
  • Patients who are on medications like tetracyclines (doxycycline etc.) or Hydantoins (phenytoin etc.) as the effectiveness of the medicines may be hampered by molindone

Side effects of the drug one or many of which may occur in different cases-

  • Drowsiness
  • Dryness  in mouth
  • Blurred  vision
  • Increased  salivation
  • Nausea
  • Constipation
  • Difficulty  in urination
  • Blank  expression on face
  • Breast  enlargement with milk production
  • Menstrual  period disorders
  • Irregular  or rapid heartbeat
  • fever with rash, sweating , muscle stiffness and neck cramps
  • fine, worm-like movements and protrusion of tongue
  • tightness in throat with difficulty in swallowing or breathing
  • seizures and tremors
  • Vision changes

Overdose of Molidone may lead to loss of consciousness or seizures